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Mutation C11994T in the mitochondrial ND4 gene is not a cause of low sperm motility in Portugal.

Pereira L, Gonçalves J, Bandelt HJ

Institute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal.

It has recently been suggested that a hitherto unobserved mutation, C11994T, causes oligoasthenozoospermia in men from India but at the same time does not affect systems other than the motility of the sperm. There are good reasons to question this proposition, in view of the worldwide mtDNA database and the Indian record in particular. We have further analyzed the oligoasthenozoospermic samples from a previous systematic study of infertile Portuguese men and found no instance of C11994T.

Published 11 March 2008 in Fertil Steril, 89(3): 738-41.
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