Infertility Research Today is a free monthly online journal that collates and summarizes the latest research about Infertility, including details on male and female infertility, treatment, causes, pregnancy.

Absence of endometrium as a cause of primary amenorrhea.

Berker B, Taşkin S, Taşkin EA

Department of Obstetrics and Gynecology, Ankara University Faculty of Medicine, Ankara, Turkey.

OBJECTIVE: To describe congenital endometrial absence. DESIGN: Case report. SETTING: University hospital. PATIENT(S): A 32-year-old woman presented with primary amenorrhea and infertility. Hormone analysis, physical and gynecologic examinations, transvaginal ultrasonography, and karyotype analysis were normal. INTERVENTION(S): Progesterone challenge test, laparoscopy, hysteroscopy were performed, and hysteroscopic biopsies were obtained from the uterine cavity. MAIN OUTCOME MEASURE(S): Presence of endometrium, menstruation. RESULT(S): The progesterone challenge test was negative. Laparoscopy revealed normal pelvic structures. Evaluation of biopsies from uterine cavity revealed absence of endometrium. CONCLUSION(S): Endometrial absence is a differential diagnosis for primary amenorrhea; assessment of the uterine cavity and obtaining biopsy samples may help in diagnosis of suspected cases before they undergo assisted reproduction and can avoid unnecessary treatment.

Published 11 March 2008 in Fertil Steril, 89(3): 723.e1-3.
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