Infertility Research Today is a free monthly online journal that collates and summarizes the latest research about Infertility, including details on male and female infertility, treatment, causes, pregnancy. | ||||||||
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Role of an estrogen-upregulated 64.0-kDa uterine fluid glycoprotein in improving fertility in women.Das T, Chattopadhyay R, Ghosh S, Goswami S, Chattopadhyay D, Chakravarty B, Kabir SN Institute of Reproductive Medicine, Kolkata, India. OBJECTIVE: To evaluate the significance of an estrogen-upregulated 64.0-kDa human uterine fluid (hUF) glycoprotein in relation to promotion of fertility. DESIGN: Prospective study. SETTING: Department of Assisted Reproductive Biology Unit, Institute of Reproductive Medicine, Kolkata. India. PATIENT(S): Sixty-three women with unexplained infertility having normal ovulatory cycle with normal endocrine profile and 18 parous women. INTERVENTION(S): Women either received no stimulation (n = 35) or were stimulated with clomiphene citrate (CC) alone (100 mg/day from day 3 to day 7; n = 56) or in combination with pure FSH (75 IU on day 3 and day 8; n = 54) and were subjected to IUI. Parous women (n = 18) receiving no treatment served as control and were followed-up for spontaneous ovulation. MAIN OUTCOME MEASURE(S): Uterine fluid protein profile, relative intensity of 64.0-kDa protein, number of mature follicles, endometrial thickness, and pregnancy. RESULT(S): Expression of the 64.0-kDa protein exhibited positive correlation with prevailing estradiol levels, but the degree of the protein response to estrogen was comparatively blunted in the CC-incorporated cycles. Endometrial thickness and pregnancy outcomes correlated positively with the expression of the protein. CONCLUSION(S): The 64.0-kDa hUF protein perhaps plays a role in endometrial receptivity to support pregnancy. Failure of pregnancy despite documented ovulation in CC-stimulated cycles may be due to its attenuating effects on expression of the protein. Published 5 February 2007 in Fertil Steril, 87(2): 343-50.
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