Infertility Research Today is a free monthly online journal that collates and summarizes the latest research about Infertility, including details on male and female infertility, treatment, causes, pregnancy.

Sperm chromosome analysis in two cases of paracentric inversion.

Vialard F, Delanete A, Clement P, Simon-Bouy B, Aubriot FX, Selva J

Departments of reproductive biology, cytogenetics, gynaecology and obstetrics, CHIPS, Poissy, France; INSERM U407, Oullins, France. fvialard@hotmail.com <fvialard@hotmail.com>

OBJECTIVE: To examine sperm meiotic segregation in men with paracentric inversions. DESIGN: Cases reports, literature review. SETTING: Departments of reproductive biology, cytogenetics, gynaecology, and obstetrics. PATIENT(S): Two patients referred for infertility, heterozygous for a paracentric inversion. INTERVENTION(S): Fluorescence in situ hybridization (FISH) with specific probes and X/Y/18 centromeric probes on 1,000 spermatozoa for the 2 patients and 10 controls. MAIN OUTCOME MEASURE(S): Sperm aneuploidy frequency. RESULT(S): The FISH analysis using the specific probes for the paracentric inversion indicated low disequilibrium (0.4% and 0.5%). The FISH analysis using X/Y/18 centromeric probes indicated aneuploidy frequencies (0.3% and 1.1%), identical to those of control patients with the same sperm parameters. CONCLUSION(S): Paracentric inversion seems to be associated with a very low risk of aneuploidy. A larger study is necessary to explore all chromosome inversions.

Published 5 February 2007 in Fertil Steril, 87(2): 418.e1-5.
Full-text of this article is available online (may require subscription).

© 2004-2008 Infertility Research Today. All Rights Reserved.