Infertility Research Today is a free monthly online journal that collates and summarizes the latest research about Infertility, including details on male and female infertility, treatment, causes, pregnancy. | ||||||||
|
Improved monofollicular ovulation in anovulatory or oligo-ovulatory women after a low-dose step-up protocol with weekly increments of 25 international units of follicle-stimulating hormone.Leader A, The Ottawa Fertility Centre, Division of Reproductive Medicine, Department of Obstetrics and Gynecology, Faculty of Medicine, University of Ottawa, Ontario, Canada. aleader@conceive.ca OBJECTIVE: To compare the effectiveness and efficiency of two low-dose step-up protocols for ovulation induction in women with anovulatory infertility (World Health Organization group II). DESIGN: Open-label, prospective, randomized, group-comparative, multicenter study. SETTING: Eighteen infertility centers in Europe and Canada. PATIENT(S): One hundred fifty-eight anovulatory or oligo-ovulatory infertile women. INTERVENTION(S): Patients were randomly assigned to one of two protocols for one cycle of follitropin beta (rFSH) using a pen device. The starting dosage was 50 IU/day for 7 days. In the absence of follicles > or =12 mm, the daily dosage was increased by either 25 or 50 IU per week. MAIN OUTCOME MEASURE(S): The percentage of all subjects treated who ovulated after one treatment cycle (efficacy) and the total rFSH dose to reach ovulation (efficiency). RESULT(S): The 25-IU group had a higher incidence of monofollicular growth (41.3% of 80 vs. 21.8% of 78 women) and ovulation (81.3% vs. 60.3%), a lower cumulative rFSH dose (887 IU vs. 984 IU), and fewer cancellations due to hyperresponse (>3 follicles > or =15 mm; 5.0% vs. 20.5%). Both protocols were well tolerated. CONCLUSION(S): Weekly increments of 25 IU in the daily dose were more effective and efficient than 50-IU increments. Published 8 June 2006 in Fertil Steril, 85(6): 1766-73.
© 2004-2008 Infertility Research Today. All Rights Reserved. |
| ||||||
