Infertility Research Today is a free monthly online journal that collates and summarizes the latest research about Infertility, including details on male and female infertility, treatment, causes, pregnancy.

The play of chance.

Collins J

Department of Obstetrics and Gynecology, McMaster University, Hamilton, Ontario, Canada. collinsj@auracom.com

Most randomized controlled trials are small relative to the clinical question they address, and chance causes more variability in the results of small trials. Thus, when small studies herald new treatment interventions, clinicians might wish to wait until the body of evidence is weighty and consistent enough to be convincing.

Published 1 May 2006 in Fertil Steril, 85(5): 1364-7; discussion 1368-70.
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