Infertility Research Today is a free monthly online journal that collates and summarizes the latest research about Infertility, including details on male and female infertility, treatment, causes, pregnancy.

Sources of heterogeneities in estimating the prevalence of endometriosis in infertile and previously fertile women.

Guo SW, Wang Y

Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin 53226-0509, USA. swguo@mcw.edu <swguo@mcw.edu>

OBJECTIVE: To identify possible sources of heterogeneity in estimates of the prevalence of endometriosis in previously fertile women and in women with infertility. DESIGN: A pooled analysis of previously published studies reporting prevalence estimates. SETTING: Academic. PATIENTS: None. INTERVENTIONS: None. MAIN OUTCOME MEASURES: None. RESULTS: There were tremendous heterogeneities in prevalence estimates for both the fertile and infertile groups. In addition, the prevalence estimates increased with the year of publication, but decreased with sample size. For previously fertile women, the heterogeneity in prevalence estimates was no longer significant after the effects of sample size and year of publication on estimates were taken into account. In the infertile group, however, there was still a sizeable heterogeneity unaccounted for after both sample size and year of publication were taken into account. CONCLUSIONS: A single prevalence estimate for the entire fertile or infertile group may be too simplistic at best. More precise prevalence estimates, likely to be age-dependent, await carefully designed and executed studies that will also record covariates such as age at surgery and referral patterns.

Published 27 November 2006 in Fertil Steril, 86(6): 1584-95.
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