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A novel missense mutation C11994T in the mitochondrial ND4 gene as a cause of low sperm motility in the Indian subcontinent.

Selvi Rani D, Vanniarajan A, Gupta NJ, Chakravarty B, Singh L, Thangaraj K

Centre for Cellular and Molecular Biology, Hyderabad, India.

We have analyzed the mitochondrial DNA of 34 oligoasthenozoospermic men along with 150 normozoospermic fertile men from the Indian subcontinent. A novel missense mutation (C11994T) in the ND4 gene, which replaces threonine with isoleucine, was observed in all of the oligoasthenozoospermic men but not in any of the normozoospermic fertile men.

Published 27 November 2006 in Fertil Steril, 86(6): 1783-5.
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