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Infertility in a man with oligoasthenoteratozoospermia associated with nonrobertsonian translocation t(9;15)(p10;q10).

Aydos SE, Tükün A

Medico-Social Center, Cebeci Hospital, Ankara University School of Medicine, Ankara, Turkey. saydos@gmail.com

OBJECTIVE: To analyze an unusual nonrobertsonian translocation t(9;15)(p10;q10) found in an infertile man with oligoasthenoteratozoospermia who had a normal phenotype. DESIGN: Case report with a review of scientific literature. SETTING: Academic research environment. PATIENT(S): Infertile man with oligoasthenoteratozoospermia but otherwise apparently healthy. INTERVENTION(S): Peripheral blood lymphocytes were obtained for karyotyping, and metaphases were studied by the GBG fluorescence in situ hybridization (FISH) procedure. MAIN OUTCOME MEASURE(S): Physical examination, semen analysis, GBG banding, and FISH procedure. RESULT(S): The semen analysis revealed oligoasthenoteratozoospermia. The lymphocytic karyotype detected a translocation t(9;15)(p10;q10), and FISH procedure showed that the derived chromosome had a chromosome 15 centromere. CONCLUSION(S): The association of unusual translocation with male factor infertility was described. To our knowledge no such association has been described previously in men whose clinical manifestation is only infertility.

Published 9 October 2006 in Fertil Steril, 86(4): 1001.e7-9.
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