Infertility Research Today is a free monthly online journal that collates and summarizes the latest research about Infertility, including details on male and female infertility, treatment, causes, pregnancy.

Ketotifen improves sperm motility and sperm morphology in male patients with leukocytospermia and unexplained infertility.

Oliva A, Multigner L

Unidad de Andrologia, Servicio de Urologia, Hospital Italiano de Rosario, Rosario, Argentina.

In an open, uncontrolled study, the effect of 12 weeks of daily administration of ketotifen, an antihistamine-like drug with a mast cell stabilizing effect, on the semen quality of 55 men with leukocytospermia and unexplained infertility was examined. After 4 weeks of treatment, white blood cell count dramatically diminished and was accompanied by a significant improvement in sperm motility. A significant increase of morphologically normal sperm cells was observed at 8 weeks of treatment, and these changes remained until at least 4 weeks after the end of treatment.

Published 17 January 2006 in Fertil Steril, 85(1): 240-3.
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