Infertility Research Today is a free monthly online journal that collates and summarizes the latest research about Infertility, including details on male and female infertility, treatment, causes, pregnancy.

Early cessation of triptorelin in in vitro fertilization: a double-blind, randomized study.

Simons AH, Roelofs HJ, Schmoutziguer AP, Roozenburg BJ, van't Hof-van den Brink EP, Schoonderwoerd SA

University Medical Center Groningen, PO Box 30.001, 0700 RB Groningen, The Netherlands. a.h.m.simons@og.umcg.nl

OBJECTIVE: To compare the efficacy of two early cessation protocols of triptorelin treatment in controlled ovarian hyperstimulation with the conventional long protocol in in vitro fertilization/intracytoplasmic sperm injection. DESIGN: A double-blind, randomized, multicenter study. SETTING: Three Dutch hospitals. PATIENT(S): One hundred seventy-eight women randomized to one of three treatment groups at the start of stimulation. INTERVENTION(S): Midluteally started triptorelin administration was continued until the first day of hMG treatment (group S), or up to and including the fourth day of hMG treatment (group M) or the day of hCG injection (group L). MAIN OUTCOME MEASURE(S): Occurrence of a premature LH surge. RESULT(S): One premature LH surge was observed in group M but not in groups S and L. Both early cessation protocols (S and M) are at least as effective as the long protocol (L) with regard to the number of oocytes (11.1 and 10.3 vs. 9.3), number of embryos (7.3 and 6.5 vs. 5.5), and ongoing pregnancy rate (28% and 24% vs. 21%). CONCLUSION(S): Early cessation of triptorelin on day 1 of hMG treatment in a midluteally started IVF protocol is as effective as the traditional long protocol in preventing a premature LH surge and results in similar fertility effects.

Published 11 April 2005 in Fertil Steril, 83(4): 889-96.
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