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A successful pregnancy outcome using frozen testicular sperm from a chimeric infertile male with a 46, XX/46, XY karyotype: case report.

Sugawara N, Tokunaga Y, Maeda M, Komaba R, Araki Y

Iwaki Women's Clinic, 3-2, Ookishita, Uchigo, Iwaki, Fukushima, 973-8403, Japan. sugawara@iwaki-fu.or.jp

BACKGROUND: We report a very rare case of the successful delivery of a healthy infant fathered by an infertile chimera. METHODS: ICSI was performed using frozen sperm. The karyotypes of peripheral lymphocytes were examined with a G-banding stain. RESULTS: Chromosomal analysis prior to ICSI revealed a 46, XX [28]/46, XY [2] karyotype chimera. As an infant, the subject was diagnosed as a true hermaphrodite, and underwent a hysterectomy and oophorectomy. A small number of sperm were found in minced testicular tissue, and they were stored for ICSI. CONCLUSION: To the best of our knowledge, this is the first case report of a successful pregnancy and delivery of a healthy infant fathered by an infertile chimera (46, XX/46, XY) following ICSI using frozen testicular sperm.

Published 16 December 2004 in Hum Reprod, 20(1): 147-8.
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